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The paper discusses general problems in using PEG for conjugation to high or low molecular weight molecules. Poly (ethylene glycol) (PEG) is a highly investigated polymer for the covalent modification of biological macromolecules and surfaces for many pharmaceutical and biotechnical applications. PEGylation is the process of covalent attachment of polyethylene glycol (PEG) polymer chains to ano...
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During the past 30 years, aPL have been demonstrated to be pathogenic [1], therefore aPL carriers should be considered at risk for clinical manifestations and managed accordingly. The problem of long-term primary prevention of thrombosis has puzzled physicians [2]. As we know from large cohorts of patients with aPL, the clinical consequences of thrombosis and its recurrence can be severe. The a...
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IN HISTORICAL REFERENCES TO WHAT TODAY WOULD BE CONSIDERED MAJOR DEPRESSION, MOOD DISORDERS HAVE LONG BEEN ASSOCIATED WITH CHANGES IN SLEEP PATTERNS. Using the term melancholia, Hippocrates (460-377 BC) already described many features, including “loss of sleep,” by which we define major depressive disorder (MDD) today. Subjective sleep complaints are frequently present in depressed patients,1,2...
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ژورنال
عنوان ژورنال: Synthesis
سال: 2004
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-2002-19807